![]() ![]() Reserve concomitant prescribing for use in patients for whom alternative treatment options are inadequate limit dosages and durations to the minimum required and follow patients for signs and symptoms of respiratory depression and sedation. Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.If prolonged opioid use is required in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available. ![]() Prolonged use of buprenorphine transdermal system during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated.Accidental exposure to buprenorphine transdermal system, especially in children, can result in fatal overdose of buprenorphine. ![]() Instruct patients on proper administration of buprenorphine transdermal system to reduce the risk. Monitor closely, especially upon initiation or following a dose increase.
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